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黃芩苷

分析標(biāo)準(zhǔn)品,HPLC≥98%

Baicalin

CAS號：21967-41-9

分子式：C21H18O11

分子量：446.37

MDL：MFCD00134418

別名：黃芩甙，貝加靈

產(chǎn)品介紹

Baicalin 作為一種類黃酮糖苷，是一種變構(gòu)肉堿棕櫚酰轉(zhuǎn)移酶1 (CPT1)是激活劑。Baicalin 降低 NF-KB表達(dá)。

熔點(diǎn)：202-205℃

沸點(diǎn)：836.6 ℃ at 760 mmHg

比旋光度：-85°(C=1, DMSO)

外觀：淡黃色結(jié)晶粉末

溶解性：DMSO  :  ≥  100  mg/mL  (224.03  mM)

H2O  :  0.1  mg/mL  (0.22  mM;  Need  ultrasonic)

儲存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(206篇)

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204. [IF=2.5] Jie Wang et al."HPMCAS-solidified supersaturated baicalin self-nanoemulsifying drug delivery systems: development and anti-colitis evaluation."PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY.

203. [IF=5.4] Ni Xu et al."Modulation of Glycolytic Metabolic Reprogramming and the TLR4/NF-κB/NLRP3 Pathway: Comparative Analysis of Anti-inflammatory Activity Between Two Dosage Forms of Pudilan Xiaoyan."JOURNAL OF ETHNOPHARMACOLOGY.2025 Jun;:120204

202. [IF=6.5] Xing Liu et al."A Baicalin Liposome-Based Temperature-Sensitive Hydrogel for Treating Ultraviolet-Induced Skin Damage."International Journal of Nanomedicine.2025 Jun;20:7935-7951

201. [IF=5.7] Huang Zhiqi et al."Sanhuang Xiexin Decoction ameliorates lipid disorders in obese mice via inducing browning of white adipose tissue and activating brown adipose tissue."Chinese Medicine.2025 Dec;20(1):1-17

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196. [IF=4.2] Hong Wei et al."Baicalin Modulates Glycolysis via the PKC/Raf/MEK/ERK and PI3K/AKT Signaling Pathways to Attenuate IFN-I-Induced Neutrophil NETosis."MEDIATORS OF INFLAMMATION.2025 May;2025(1):8822728

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193. [IF=2] Li Yifan et al."Probiotic nanovesicles encapsulating baicalin: a strategy to overcome colorectal cancer."LETTERS IN APPLIED MICROBIOLOGY.2024 Nov;:

192. [IF=4.4] Dan Song et al."The mechanism of baicalin in improving pulmonary inflammatory response and injury and regulating intestinal flora in Mycoplasma pneumoniae pneumonia mice."CELLULAR SIGNALLING.2025 Feb;126:111530

191. [IF=4.6] Yiyuan Pan et al."Baicalin promotes β-1,3-glucan exposure in Candida albicans and enhances macrophage response."Frontiers in Cellular and Infection Microbiology.2024 Dec;14:

190. [IF=14.3] Shaoqi Qu et al."A Milk Extracellular Vesicle-Based Nanoplatform Enhances Combination Therapy Against Multidrug-Resistant Bacterial Infections."Advanced Science.2024 Dec;:2406496

189. [IF=4.9] Xin Zuo et al."Functional Characterization of β-Glucuronidase Genes Involved in Baicalein Biosynthesis from Scutellaria baicalensis Based on Transcriptome Analysis."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2025 Jan;26(5):1793

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187. [IF=4.2] Xiaoqi Ban et al."In-depth analysis of surface selective adsorption and interfacial mechanisms in the efficient flotation separation of magnesite and dolomite with the environmentally friendly inhibitor baicalin."ADVANCED POWDER TECHNOLOGY.2025 Jun;36:104

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183. [IF=3.9] Jin Dai et al."Study on the anti-atherosclerosis mechanisms of Tanyu Tongzhi formula based on network pharmacology, Mendelian randomization, and experimental verification."PHARMACEUTICAL BIOLOGY.

182. [IF=7.7] Zhou Li et al."Carboxymethyl chitosan-modified folate-targeted carbon nanotube-baicalin complexes for cancer progression and metastasis."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024 Oct;:136896

181. [IF=6.7] Tong Tian et al."Qingfei Yin alleviates Streptococcus pneumoniae pneumonia by promoting complete autophagy to suppress necroptosis."PHYTOMEDICINE.2024 Nov;:156280

180. [IF=3.2] Jiahao Zhang et al."Baicalin-Geniposide glycosides inhibit PM2.5-induced brain damage in rats via the 5-LOX/LTB4 pathway."MOLECULAR IMMUNOLOGY.2025 Jan;177:62

179. [IF=11.4] Yameng Cui et al."Baicalin attenuates the immune escape of oral squamous cell carcinoma by reducing lactate accumulation in tumor microenvironment."Journal of Advanced Research.2025 Jan;:

178. [IF=7.7] Mengjiao Li et al."Study on network cross-linked hydrogel with cationic Bletilla striata polysaccharide/carbopol as a drug delivery system."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 Feb;:140778

177. [IF=5.7] Yiqing Cai et al."Baicalin mitigates hyperglycemia-linked intestinal epithelial barrier impairment in part by inhibiting the formation of neutrophil extracellular traps."Frontiers in Immunology.2025 Mar;16:

176. [IF=2.9] Tian Hu et al."Baicalin-Geniposide combination modulates microglia polarization against chronic cerebral ischemia and concomitant kidney injury via the HIF-1α/EPO/NF-κB pathway."JOURNAL OF NEUROIMMUNOLOGY.2025 Jun;403:578601

175. [IF=4.9] Zhongda Cao et al."Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2024 Jan;25(18):9930

174. [IF=7.7] Zhenjiang Zheng et al."Growth inhibition of pancreatic cancer by targeted delivery of gemcitabine via fucoidan-coated pH-sensitive liposomes."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024 Oct;277:134517

173. [IF=2.7] Siqi Zhu et al."Baicalin attenuated oxidative stress and inflammation in ethylene glycol-induced urolithiasis in adult male SD rats."TISSUE & CELL.2024 Jun;:102453

172. [IF=6.9] You Yi-ping et al."Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages."ACTA PHARMACOLOGICA SINICA.2024 Sep;:1-18

171. [IF=4.8] Yongqiang Wen et al."Uncovering the protective mechanism of baicalin in treatment of fatty liver based on network pharmacology and cell model of NAFLD."INTERNATIONAL IMMUNOPHARMACOLOGY.2024 Nov;141:112954

170. [IF=6.2] Jingzheng Li et al."Baicalin ameliorates heat stress-induced hepatic injury and intestinal microecology dysbiosis in late gestational mice."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2024 Sep;283:116832

169. [IF=7.2] Li Huang et al."Development of cantharidin/baicalin co-delivery system based on mitochondrial targeting strategy for enhanced hepatocellular carcinoma therapy."Applied Materials Today.2024 Oct;40:102374

168. [IF=13] Yujie Fan et al."Coordination-Driven Nanomedicine Mitigates One-Lung Ventilation-Induced Lung Injury via Radicals Scavenging and Cell Pyroptosis Inhibition."Small.2024 Aug;:2401056

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166. [IF=6.7] Xianli Xu et al."Bu-Shen-Ning-Xin decoction ameliorates premature ovarian insufficiency by suppressing oxidative stress through rno_circRNA_012284/rno_miR-760-3p/HBEGF pathway."PHYTOMEDICINE.2024 Jul;:155920

165. [IF=4.3] Hujun Du et al."Exploring the Underlying Mechanisms of Qingxing Granules Treating H1N1 Influenza Based on Network Pharmacology and Experimental Validation."Pharmaceuticals.2024 Jun;17(6):731

164. [IF=5.4] Dan Yang et al."Study on the Effect of Pharmaceutical Excipient PEG400 on the Pharmacokinetics of Baicalin in Cells Based on MRP2, MRP3, and BCRP Efflux Transporters."Pharmaceutics".2024 Jun;16(6):731

163. [IF=5.4] Rui Guo et al."Tanreqing injection inhibits influenza virus replication by promoting the fusion of autophagosomes with lysosomes: An integrated pharmacological study."JOURNAL OF ETHNOPHARMACOLOGY".2024 Apr;:118159

162. [IF=7.5] Yanfang Zheng et al."Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin’s neuroprotective action against diabetes-induced cognitive impairment."BIOMEDICINE & PHARMACOTHERAPY".2024 May;174:116579

161. [IF=5.4] Ruolan Sun et al."Homotherapy-for-heteropathy of Bupleurum Chinense DC.-Scutellaria baicalensis Georgi in treating depression and colorectal cancer: A network pharmacology and animal model approach."JOURNAL OF ETHNOPHARMACOLOGY".2024 Mar;:118038

160. [IF=3.4] Yanhua Jiang et al."Network pharmacology combined with lipidomics to reveal the regulatory effects and mechanisms of Kangzao granules in the hypothalamus of rats with central precocious puberty."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS".2024 May;

159. [IF=4.9] Huang Hefei et al."Tanreqing injection inhibits dengue virus encephalitis by suppressing the activation of NLRP3 inflammasome."Chinese Medicine".2024 Dec;19(1):1-17

158. [IF=5.6] Heng Sun et al."Molecular-Scale Investigations Reveal the Effect of Natural Polyphenols on BAX/Bcl-2 Interactions."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES".2024 Jan;25(5):2474

157. [IF=5.6] Haipeng Feng et al."Baicalin Protects Broilers against Avian Coronavirus Infection via Regulating Respiratory Tract Microbiota and Amino Acid Metabolism."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES".2024 Jan;25(4):2109

156. [IF=7.9] Yanqin Luo et al."Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota."PHYTOMEDICINE".2024 May;:155706

155. [IF=5.2] Zhixia Wang et al."A carrier-free organometallic hydrogel originated from natural baicalin and Zn2+ with antibacterial and antioxidant efficacy."COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS.2023 Dec;679:132585

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153. [IF=0.7] Xianyong Li et al."Baicalin Promotes Apoptosis of Human Medullary Breast Cancer via the ERK/p38 MAPK Pathway."Pharmacognosy Magazine.;():

152. [IF=3] Weiwei Dai et al."Baicalin alleviates oxygen–glucose deprivation/reoxygenation-induced SK-N-SH cell injury via the regulation of miR-556-3p/ACSL4 pathway."Chemical Biology & Drug Design.2024 Jan;103(2):e14455

151. [IF=5] Ren Yanying et al."Quercetin: a promising virulence inhibitor of Pseudomonas aeruginosa LasB in vitro."APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.2024 Dec;108(1):1-20

150. [IF=1.8] Yue Qian et al."Si Miao San relieves hyperuricemia by regulating intestinal flora."BIOMEDICAL CHROMATOGRAPHY.2023 Dec;:e5807

149. [IF=2.9] Qi Ying et al."Sanhuang Xiexin Decoction Ameliorates TNBC By Modulating JAK2-STAT3 and Lipid Metabolism."Chinese Journal of Integrative Medicine.2023 Nov;:1-10

148. [IF=5.4] Liangxin Zhao et al."UPLC-Q-Exactive/MS based analysis explore the correlation between components variations and anti-influenza virus effect of four quantified extracts of Chaihu Guizhi decoction."JOURNAL OF ETHNOPHARMACOLOGY.2023 Oct;:117318

147. [IF=3.3] Li Li et al."Baicalin promotes antiviral IFNs production and alleviates type I IFN-induced neutrophil inflammation."Journal of Natural Medicines.2023 Jul;:1-11

146. [IF=4.3] Bao-Fei Yan et al."Huangqin decoction alleviates lipid metabolism disorders and insulin resistance in nonalcoholic fatty liver disease by triggering Sirt1/NF-κB pathway."WORLD JOURNAL OF GASTROENTEROLOGY.2023 Aug 21; 29(31): 4744–4762

145. [IF=6] Shuai Yan et al."Baicalin Suppresses Colorectal Cancer Cell Proliferation, Potentially via ARRDC4: Bioinformatics and Experimental analysis."Arabian Journal of Chemistry.2023 Jul;:105141

144. [IF=5.2] Guo Huanyu et al."The combined effect of a novel formula of herbal extracts on bacterial infection and immune response in Micropterus salmoides."Frontiers in Microbiology.2023 Jun;14:

143. [IF=5.4] Miaomiao Liu et al."Qingjin Huatan decoction protects mice against influenza a virus pneumonia via the chemokine signaling pathways."JOURNAL OF ETHNOPHARMACOLOGY.2023 Dec;317:116745

142. [IF=7.5] Jingwen Yuan et al."Baicalin enhances the efficacy of 5-Fluorouracil in gastric cancer by promoting ROS-mediated ferroptosis."BIOMEDICINE & PHARMACOTHERAPY.2023 Aug;164:114986

141. [IF=3.976] Su Jianqing et al."Pharmacokinetic Studies of Hyperoside-2-hydroxypropyl-β-cyclodextrin Inclusion Complex and It Ameliorated DSS-Induced Colitis in Mice."BIOSCIENCE REPORTS.2023 May;:

140. [IF=4.221] Xixi Fan et al."Baicalin inhibits the replication of the hepatitis B virus by targeting TRIM25."Journal of Traditional and Complementary Medicine.2023 May;:

139. [IF=6.388] Jialing Sun et al."Baicalin inhibits hepatocellular carcinoma cell growth and metastasis by suppressing ROCK1 signaling."PHYTOTHERAPY RESEARCH.2023 May;:

138. [IF=9.965] Junxiao Zhu et al."Are all poorly soluble drugs dissolved in deep eutectic solvents true solutions?."JOURNAL OF COLLOID AND INTERFACE SCIENCE.2023 Sep;645:813

137. [IF=2.139] Y Zhang et al."Baicalin alleviates silica-induced lung inflammation and fibrosis by inhibiting TLR4/NF-?B pathway in rats."PHYSIOLOGICAL RESEARCH.2023 Apr 30;72(2):221-233

136. [IF=2.742] Li Mengyuan et al."Baicalin can enhance odonto/osteogenic differentiation of inflammatory dental pulp stem cells by inhibiting the NF-κB and β-catenin/Wnt signaling pathways."MOLECULAR BIOLOGY REPORTS.2023 Apr;:1-12

135. [IF=9.429] Su Wenting et al."An intravitreal-injectable hydrogel depot doped borneol-decorated dual-drug-coloaded microemulsions for long-lasting retina delivery and synergistic therapy of wAMD."JOURNAL OF NANOBIOTECHNOLOGY.2023 Dec;21(1):1-19

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133. [IF=4.927] Bingyu Shen et al."Baicalin Relieves LPS-Induced Lung Inflammation via the NF-κB and MAPK Pathways."MOLECULES.2023 Jan;28(4):1873

132. [IF=7.419] Mengli Li et al."Baicalin mitigates hypertension-linked alterations in the intestinal lymphatic vasculature in part through preserving the functional barrier integrity of lymphatic endothelial cells."BIOMEDICINE & PHARMACOTHERAPY.2023 Apr;160:114418

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127. [IF=6.525] Xingxing Dai et al."Diammonium Glycyrrhizinate-Based Micelles for Improving the Hepatoprotective Effect of Baicalin: Characterization and Biopharmaceutical Study."Pharmaceutics.2023 Jan;15(1):125

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125. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199

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123. [IF=6.208] Pan Wang et al."Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure–Activity Relationship and Inhibition Profiles."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022 Jan;23(18):10747

122. [IF=2.721] Haipeng  Feng et al."Antiviral activity and underlying mechanisms of Baicalin against avian infectious bronchitis virus in vitro."AVIAN PATHOLOGY

121. [IF=5.988] Qihan Luo et al."Chang qing formula ameliorates colitis-associated colorectal cancer via suppressing IL-17/NF-κB/STAT3 pathway in mice as revealed by network pharmacology study."Frontiers in Pharmacology.2022; 13: 893231

120. [IF=6.212] Fei Huang et al."Discovery of conversion driven by β-glucuronidase from flavone glycoside to aglycone and application in identifying the raw Scutellariae Radix."Arabian Journal of Chemistry.2022 Aug;:104216

119. [IF=3.322] Dongjiu Zhao et al."Baicalin promotes antibacterial defenses by modulating mitochondrial function."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2022 Sep;621:130

118. [IF=5.195] Mengmeng Song et al."Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents."JOURNAL OF ETHNOPHARMACOLOGY.2022 Jul;:115545

117. [IF=8.025] Ying Wang et al."Inhibitory activities of flavonoids from Scutellaria baicalensis Georgi on amyloid aggregation related to type 2 diabetes and the possible structural requirements for polyphenol in inhibiting the nucleation phase of hIAPP aggregation."INT

116. [IF=3.935] Yizhu Wang et al."Effects of Scutellaria baicalensis Georgi. on Intestinal Flora in Rats with Spleen Deficiency and Damp-heat."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114831

115. [IF=5.095] Liu  Fengjie et al."Baicalin-loaded folic acid-modified albumin nanoparticles (FA-BSANPs/BA) induce autophagy in MCF-7 cells via ROS-mediated p38 MAPK and Akt/mTOR pathway."Cancer Nanotechnol. 2022 Dec;13(1):1-21

114. [IF=4.072] He Pang et al."Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways."J Bone Oncol. 2022 Apr;33:100415

113. [IF=3.205] Wanli Ji et al."Revealing therapeutic targets and mechanism of baicalin for anti-chronic gastritis using proteomic analysis of the gastric tissue."J Chromatogr B. 2022 Mar;:123214

112. [IF=2.193] Zhang Haibo et al.Systematic Study on a Quantitative Analysis of Multicomponents by Single Marker (QAMS) Method for Simultaneous Determination of Eight Constituents in Pneumonia Mixture by UPLC-MS/MS.J Anal Methods Chem. 2021;2021:8311588

111. [IF=4.36] Jiali Zhou et al.The root extract of Scutellaria baicalensis Georgi promotes β cell function and protects from apoptosis by inducing autophagy.J Ethnopharmacol. 2022 Feb;284:114790

110. [IF=1.625] Hong-Jing Sun et al."Baicalin Alleviates Age-Related Macular Degeneration via miR-223/NLRP3-Regulated Pyroptosis."Pharmacology. 2020;105(1-2):28-38

109. [IF=1.851] Rui  Li et al."Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR?146a."Mol Med Rep. 2019 Dec;20(6):5041-5049

108. [IF=1.913] Zheng XP et al."Kidney-targeted baicalin-lysozyme conjugate ameliorates renal fibrosis in rats with diabetic nephropathy induced by streptozotocin.."Bmc Nephrol. 2020 May;21(1):174-174

107. [IF=2.193] Xue Gen et al."Integrating Study on Qualitative and Quantitative Characterization of the Major Constituents in Shuanghuanglian Injection with UHPLC/Q-Orbitrap-MS and UPLC-PDA."J Anal Methods Chem. 2021;2021:9991363

106. [IF=2.193] Xu Tong et al."A Preferable Approach for the Quality Control of Xiaoer Chiqiao Qingre Granules Based on the Combination of Chromatographic Fingerprints and Chemometrics."J Anal Methods Chem. 2020;2020:6836981

105. [IF=2.877] Wanli Ji et al."Identifying the active compounds and mechanism of action of Banxia Xiexin decoction for treating ethanol-induced chronic gastritis using network pharmacology combined with UPLC–LTQ–Orbitrap MS."Comput Biol Chem. 2021 Aug;93:107535

104. [IF=3] Qu  Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950

103. [IF=3.361] Mengmeng Yuan et al."The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects."Rsc Adv. 2019 Apr;9(19):10781-10788

102. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328

101. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002

100. [IF=3.935] Meng Chen et al."Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate."J Pharmaceut Biomed. 2021 Feb;195:113820

99. [IF=3.935] Chenglong Sun et al."A spatially-resolved approach to visualize the distribution and biosynthesis of flavones in Scutellaria baicalensis Georgi."J Pharmaceut Biomed. 2020 Feb;179:113014

98. [IF=4.162] Leyi Ma et al."Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway."Drug Des Dev Ther. 2021; 15: 3207–3221

97. [IF=4.225] Wu  Dandan et al."Baicalin Protects Against Hypertension-Associated Intestinal Barrier Impairment in Part Through Enhanced Microbial Production of Short-Chain Fatty Acids."Front Pharmacol. 2019 Oct;0:1271

96. [IF=4.545] Xiangyan Wu et al."Qingda granules attenuate hypertensive cardiac remodeling and inflammation in spontaneously hypertensive rats."Biomed Pharmacother. 2020 Sep;129:110367

95. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625

94. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra

93. [IF=5.11] Xiaonan Liu et al."De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae."Acs Synth Biol. 2020;9(11):3042–3051

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