執(zhí)照.jpg)
苦參堿
分析標準品,HPLC≥98%
Matrine
CAS號：519-02-8
分子式：C15H24N2O
分子量：248.36
MDL：MFCD00210527
貨號 | 規(guī)格/參數(shù)/品牌 | 價格 | 貨期 |
YJ-B20679-20mg | 分析標準品,HPLC≥98% | ￥180.00 | 現(xiàn)貨 |
YJ-B20679-100mg | 分析標準品,HPLC≥98% | ￥480.00 | 現(xiàn)貨 |
JS31035-1g | 試劑級，98% | ￥145.00 | 現(xiàn)貨 |
JS31035-5g | 試劑級，98% | ￥310.00 | 現(xiàn)貨 |
JS31035-25g | 試劑級，98% | ￥610.00 | 現(xiàn)貨 |
JS31035-100g | 試劑級，98% | ￥2050.00 | 現(xiàn)貨 |
A10165-20mg | 分析標準品,含量99.5%，可溯源 | ￥290.00 | 現(xiàn)貨 |
JT94661-1ml買5贈1 | 10mM in DMSO | ￥1020.00 | 現(xiàn)貨 |
產(chǎn)品介紹
Matrine (Matridin-15-one) 是一種在槐屬植物中發(fā)現(xiàn)的生物堿，可作為 kappa 阿片受體和 u-受體激動劑。Matrine 具有多種藥理作用，包括抗癌、抗氧化應激、抗炎和抗凋亡作用，可用于人類非小細胞肺癌、肝癌、甲狀腺乳頭狀癌和急性腎損傷 (AKI) 等疾病的研究。
熔點：77 ℃
沸點：396.7 ℃ at 760 mmHg
比旋光度：(C=1, EtOH)+33
外觀：針狀或棱狀結(jié)晶
溶解性：DMSO:≥50mg/mL(201.32mM)
H2O:20mg/mL(80.53mM;Needultrasonic)
儲存條件：2-8℃
注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。
參考文獻(60篇)
60. [IF=2.5] Sidan Zhao et al."Efficient Extraction of Alkaloids From Sophora moorcroftiana Seeds via Enzyme and Ultrasound-Assisted Coupling and Their Antibacterial Activity."CHEMISTRY & BIODIVERSITY.2025 Jul;:e00635
59. [IF=4.5] Qinghua Yang et al."Eutectogel based on multi-functional deep eutectic solvent for acne infection treatment."JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY.2024 Nov;101:106260
58. [IF=4.9] Bo Yang et al."A liquid chromatography-tandem mass spectrometry method to determine total matrine residues in edible porcine tissues and its application in a tissue residue depletion study."MICROCHEMICAL JOURNAL.2024 Nov;:112139
57. [IF=5.3] Peijie Wang et al."Potential application of matrine microneedles for the treatment of atopic dermatitis in joint skin."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2025 Jan;668:124992
56. [IF=2.8] Zhuoni Liu et al."Eutectic Solvents Based on Matrine and Fatty Acids as Solubility and Stability Enhancers of Curcumin."JOURNAL OF PHYSICAL CHEMISTRY B.2025;XXXX(XXX):XXX-XXX
55. [IF=5.3] Pan-Pan Gu et al."Activation of bitter taste receptor TAS2R4 alleviates diabetic nephropathy in mice."BIOCHEMICAL PHARMACOLOGY.2025 Apr;:116941
54. [IF=2.8] Wenkui Zou et al."Unveiling the Mechanism of Compound Ku-Shen Injection in Liver Cancer Treatment through an Ingredient–Target Network Analysis."Genes.2024 Oct;15(10):1278
53. [IF=4.9] Zhongda Cao et al."Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2024 Jan;25(18):9930
52. [IF=3.8] Jinwu Meng et al."The synergy effect of matrine and berberine hydrochloride on treating colibacillosis caused by an avian highly pathogenic multidrug-resistant Escherichia coli."POULTRY SCIENCE.2024 Jul;:104151
51. [IF=2.3] Meng Jinwu et al."Reversal of gentamicin sulfate resistance in avian pathogenic Escherichia coli by matrine combined with berberine hydrochloride."ARCHIVES OF MICROBIOLOGY.2024 Jul;206(7):1-14
50. [IF=7.5] Xue Li et al."Matrine induces autophagic cell death by triggering ROS/AMPK/mTOR axis and apoptosis in multiple myeloma."BIOMEDICINE & PHARMACOTHERAPY".2024 Jun;175:116738
49. [IF=5] Ruiyang Jiang et al."Sophocarpine alleviates intestinal fibrosis via inhibition of inflammation and fibroblast into myofibroblast transition by targeting the Sirt1/p65 signaling axis."EUROPEAN JOURNAL OF PHARMACOLOGY".2024 Mar;967:176318
48. [IF=5.2] Zhao Jingchao et al."Matrine reverses the resistance of Haemophilus parasuis to cefaclor by inhibiting the mutations in penicillin-binding protein genes (ftsI and mrcA)."Frontiers in Microbiology".2024 Feb;15:
47. [IF=10] Congyan Liu et al."A Sustainable Retinal Drug Co-Delivery for Boosting Therapeutic Efficacy in wAMD: Unveiling Multifaceted Evidence and Synergistic Mechanisms."Advanced Healthcare Materials".2024 Mar;:2303659
46. [IF=5.4] Xinxin Wu et al."The therapeutic efficacy and mechanism action of Si Cao formula in the treatment of psoriasis: A pilot clinical investigation and animal validation."JOURNAL OF ETHNOPHARMACOLOGY.2024 Apr;323:117662
45. [IF=5] Menghan Li et al."Therapeutic deep eutectic solvents based on natural product matrine and caprylic acid: Physical properties, cytotoxicity and formation of surfactant free microemulsion."JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY.2023 Dec;90:105177
44. [IF=4.6] Wei Shijie et al."MAT as a promising therapeutic strategy against triple-negative breast cancer via inhibiting PI3K/AKT pathway."Scientific Reports.2023 Jul;13(1):1-12
43. [IF=4.7] Chen Zihan et al."Liquid chromatography-tandem mass spectrometry analysis of a ratio-optimized drug pair of Sophora flavescens Aiton and Coptis chinensis Franch and study on the mechanism of anti-colorectal cancer effect of two alkaloids thereof."Frontier
42. [IF=8.44] Zhang Ming et al."Matrine alleviates depressive-like behaviors via modulating microbiota–gut–brain axis in CUMS-induced mice."Journal of Translational Medicine.2023 Dec;21(1):1-18
41. [IF=4.462] Zheng Sun et al."Matrine can be absorbed and transmitted bidirectionally to defend against aphids (Hemiptera: Aphididae) on wheat and pepper."PEST MANAGEMENT SCIENCE.2023 Feb;:
40. [IF=2.13] Xinfeng Chang et al."Matrine inhibits hepatocellular carcinoma cell malignancy through the circ_0013290/miR-139-5p/MMP16 pathway."HISTOLOGY AND HISTOPATHOLOGY.2022 Dec 14;18574
39. [IF=4.966] Yang Li et al."Functional analysis of 3 genes in xenobiotic detoxification pathway of Bursaphelenchus xylophilus against matrine."PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY.2023 Feb;190:105334
38. [IF=3.024] Xuan Yu et al."An innovative extraction strategy for herbal medicine by adopting p-sulphonatocalix[6]/[8]arenes."PHYTOCHEMICAL ANALYSIS
37. [IF=1.978] Chen Ming-jun et al."Composite Sophora Colon-Soluble Capsule Ameliorates DSS-Induced Ulcerative Colitis in Mice via Gut Microbiota-Derived Butyric Acid and NCR+ ILC3."Chin J Integr Med. 2022 Apr;:1-10
36. [IF=5.165] Juanning Ren et al."Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement."Arab J Chem. 2022 Jun;15:103825
35. [IF=2.1] Jikun Du et al."Matrine exerts anti?breast cancer activity by mediating apoptosis and protective autophagy via the AKT/mTOR pathway in MCF?7 cells."Mol Med Rep. 2020 Nov;22(5):3659-3666
34. [IF=2.447] Guanglei Wang et al."Matrine ameliorates the inflammatory response and lipid metabolism in vascular smooth muscle cells through the NF?κB pathway."Exp Ther Med. 2021 Nov;22(5):1-8
33. [IF=4.268] Qing Zhao et al."The water extract of Sophorae tonkinensis Radix et Rhizoma alleviates non-alcoholic fatty liver disease and its mechanism."Phytomedicine. 2020 Oct;77:153270
32. [IF=4.932] Sihao Zheng et al."Combination of matrine and tacrolimus alleviates acute rejection in murine heart transplantation by inhibiting DCs maturation through ROS/ERK/NF-κB pathway."Int Immunopharmacol. 2021 Dec;101:108218
31. [IF=1.448] Wang Xie et al."Matrine inhibits the proliferation and migration of lung cancer cells through regulation of the protein kinase B/glycogen synthase kinase?3β signaling pathways."Exp Ther Med. 2018 Aug;16(2):723-729
30. [IF=3.943] Kangfeng Jiang et al."Matrine alleviates Staphylococcus aureus lipoteichoic acid-induced endometritis via suppression of TLR2-mediated NF-κB activation."Int Immunopharmacol. 2019 May;70:201
29. [IF=4.411] Jifeng Gu et al."Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements."Molecules. 2018 Apr;23(4):884
28. [IF=5.81] Shang Xiaofei et al."The Anti-diarrheal Activity of the Non-toxic Dihuang Powder in Mice."Front Pharmacol. 2018 Sep;0:1037
27. Valkó, Klára. "Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution." Journal of chromatography A 1037.1-2 (2004): 299-310.https:##doi.org/10.1016/j.chroma.2003.10.084
24. Diao, Jian, et al. "Bioinformatics analysis of structure and function in the MRP gene family and its expression in response to various drugs in Bursaphelenchus xylophilus." Journal of Forestry Research 32.2 (2021): 779-787.https:##doi.org/10.1007/s11676-01
23. Jiang, Kangfeng, et al. "Matrine alleviates Staphylococcus aureus lipoteichoic acid-induced endometritis via suppression of TLR2-mediated NF-κB activation." International immunopharmacology 70 (2019): 201-207.https:##doi.org/10.1016/j.intimp.2019.02.033
22. 鄭榮芳,劉偉,張蕓中,樊學芬,郭鈺珍.苦參堿調(diào)控Wnt/β-catenin途徑抑制宮頸癌細胞系Caski細胞侵襲遷移[J].南京醫(yī)科大學學報(自然科學版),2021,41(01):35-40.
21. 陽麗梅,陳淑芳,黃旭慧,莊捷.苦參堿調(diào)控PXR-CYP3A4通路對石膽酸誘導肝損傷細胞系的保護作用[J].中國藥學雜志,2020,55(21):1802-1806.
20. 崔鮮偉,鄧桂明,歐陽林旗,陳鎮(zhèn),何怡然,孫文靜,王勝玫,劉濤.納米脂質(zhì)體制劑提高苦參堿去活化肝星狀細胞作用研究[J].藥物評價研究,2021,44(01):63-69.
19. 程明剛,肖若蕾,袁侶明,程夢玲,余海峰.苦參堿脂質(zhì)體凝膠的含量測定[J].湖北科技學院學報(醫(yī)學版),2020,34(06):464-466.
18. 李旭,陳嵐,岳園,于軍.苦參堿對肝癌細胞HepG2生長凋亡的作用及機制[J].中國老年學雜志,2020,40(18):3944-3947.
17. 張清華, 陸芝, 張曉陽,等. 桉樹焦枯病菌MDR基因生物信息學分析及功能解析[J]. 福建農(nóng)林大學學報:自然科學版, 2019, 048(001):88-96.
16. 王玲 張婷 錢大瑋 等. 3種辛味中藥揮發(fā)油對苦參生物堿類成分透皮吸收的影響[J]. 中國中藥雜志 2019 v.44(02):110-115.
15. 仲金秋, 曹玉珠, 徐宏江,等. 甘草酸二銨改善ConA致小鼠肝損傷的作用研究[J]. 天然產(chǎn)物研究與開發(fā), 2018, 30(12):60-68.
14. 宋精梅, 陳思邈, 陳冰,等. 川芎苦參不同比例配伍對活性成分和抗氧化活性的影響[J]. 中國中醫(yī)急癥, 2020(1):87-90.
13. 張偉 馬桂芝 王春芳 等. 一測多評法測定銀屑配方顆粒中4種生物堿的含量[J]. 西北藥學雜志 2018(5):595-600.
12. 施曉瑩 談文盼 宋麗軍 等. HPLC-MS檢識苦豆子總堿雙層包衣微丸入血成分[J]. 遼寧中醫(yī)藥大學學報 2019 021(004):65-69.
11. 夏藝 毛芬蘭 向蘇 等. HPLC法測定酒炙苦參中三種生物堿的含量[J]. 中國藥師 2018(1):146-148.
10. 陽麗梅, 黃旭慧, 張倩文,等. 苦參堿預防大鼠膽汁淤積性肝損傷作用機制的研究[J]. 福建醫(yī)藥雜志, 2019(5):8-12.
9. 趙淑婷, 雷蕾, 程靜新. 苦參堿通過P38通路調(diào)節(jié)H2AX磷酸化抑制宮頸癌細胞的增殖及遷移[J]. 同濟大學學報(醫(yī)學版), 2018, 039(004):22-28.
8. 崔勝男, 邢秀菊. 苦參堿誘導H466肺癌細胞凋亡及對Wnt信號通路的影響[J]. 臨床肺科雜志, 2020, v.25(03):87-91.
7. 胡欣夢,宋雅珊,麻銳,潘玲,廖蘊華,伍巧源.苦參堿對順鉑誘導的腎小管上皮細胞損傷的保護作用[J].廣西醫(yī)科大學學報,2019,36(05):706-710.
6. 古月瑜, 廖曉忠, 劉嘉輝,等. 苦參堿對人孕烷X受體介導的CYP3A4調(diào)節(jié)及藥物相互作用分析.
5. 陽麗梅, 黃旭慧, 曹娃,等. 苦參堿對α-萘異硫氰酸酯誘導的大鼠膽汁淤積性肝損傷的作用[J]. 中國藥學雜志, 2018, 53(010):783-787.
4. 毛東霞, 郭丹丹, 吳玲玲,等. 石油污染土壤中產(chǎn)苦參堿真菌的分離與鑒定[J]. 浙江大學學報(農(nóng)業(yè)與生命科學版), 2015, 41(5):586-592.
3. 郝昕, 王峰, 馬玲,等. 松材線蟲耐藥基因克隆及其功能[J]. 東北林業(yè)大學學報, 2018.
2. 陳天朝 常倩倩 馬彥江 等. 不同物料性質(zhì)的模型丸劑在大鼠體內(nèi)藥物代謝動力學研究[J]. 中醫(yī)學報 2018 v.33；No.240(05):136-140.
1. 陳天朝 于蘭蘭 劉瑞霞 等. 不同物料參數(shù)及配比對模型丸劑體外溶出的影響[J]. 中華中醫(yī)藥學刊 2017 035(011):2899-2902.
從2011年開始我們致力于在生命科學領(lǐng)域、生物醫(yī)學實驗技術(shù)及論文潤色服務(wù)，協(xié)助客戶各類實驗服務(wù)及論文潤色十余年，是客戶您值得信賴的科研合作伙伴!
如果您受時間、試驗條件等限制而無法完成您的課題研究，歡迎您與我們聯(lián)系。
實驗技術(shù)服務(wù)：
